"Oncology researchers have tried a variety of methods for blocking faulty MMPs, but they’ve frequently failed to do so without also affecting normal MMPs and causing side effects"
Side effects are a frequent problem with many drugs today. Often times you will have to take another drug to counter act the first drugs side effect. It is a seemingly never ending cycle. Side effects are also a reason why people don't take their medication properly. They are afraid of how it will make them feel or how they will respond to it. Researchers have found that altering MMP's can help with Cancer, MS, and other diseases. However they stopped their trials due to the side effects that have occurred. A lot of drugs get approved even with the ridiculous amount of side effects so there must have been very serious side effects here.
Lodonal (LDN) works by boosting levels of endorphins (peptides produced in the brain and adrenal glands) that are best known for relieving pain and enhancing your sense of well-being. Endorphins are responsible for the “runner's high” brought on by strenuous exercise. These natural peptides are also powerful modulators of the immune system.
"All sources indicate that LDN has virtually no side effects. Some patients report vivid dreams, andoccasionally, during the first week of use, patients may complain of difficulty sleeping. (Reports indicate that sleep disturbance is rare, occurring in less than 2% of users.) If this persists after the first week, dosage can be reduced from 4.5mg to 3mg"